Assay Detail
Binding
CHEMBL763247
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ram seminal vesicle Cyclooxygenase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Tissue | Seminal vesicle |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Prostaglandin G/H synthase (cyclooxygenase) (CHEMBL2111358) ↗| Type | PROTEIN FAMILY |
| Organism | Ovis aries |
Publication
Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.50 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.82 |
| CHEMBL284827 | — | — | 1 | 4.17 |
| CHEMBL30395 | — | — | 1 | - |
| CHEMBL284356 | — | — | 1 | - |
| CHEMBL286308 | — | — | 1 | - |
| CHEMBL267473 | DAZOXIBEN | 2.0 | 1 | - |
| CHEMBL540 | IMIDAZOLE | — | 1 | - |
| CHEMBL286092 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL284827 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL30395 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL284356 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL286308 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL267473 | DAZOXIBEN | IC50 | > | 100000.0 | nM | - |
| CHEMBL540 | IMIDAZOLE | IC50 | > | 10000000.0 | nM | - |
| CHEMBL286092 | — | IC50 | > | 100000.0 | nM | - |