Assay Detail
Functional
CHEMBL763252
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptor
14
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Prostaglandin E2 receptor EP4 subtype (CHEMBL2489) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Design and synthesis of a highly selective EP4-receptor agonist. Part 2: 5-thia and 9beta-haloPG derivatives with improved stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.63 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292964 | — | — | 1 | 8.80 |
| CHEMBL495 | ALPROSTADIL | 4.0 | 2 | 8.60 |
| CHEMBL291630 | — | — | 1 | 8.48 |
| CHEMBL64187 | — | — | 1 | 8.44 |
| CHEMBL294108 | — | — | 1 | 8.43 |
| CHEMBL439934 | — | — | 1 | 7.85 |
| CHEMBL293647 | — | — | 1 | 7.70 |
| CHEMBL63061 | — | — | 1 | 7.36 |
| CHEMBL64188 | — | — | 1 | 7.34 |
| CHEMBL60894 | — | — | 1 | 6.80 |
| CHEMBL64072 | — | — | 1 | 6.57 |
| CHEMBL62868 | — | — | 1 | 6.00 |
| CHEMBL60555 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292964 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL495 | ALPROSTADIL | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL291630 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL64187 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL495 | ALPROSTADIL | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL294108 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL439934 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL293647 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL63061 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL64188 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL60894 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL64072 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL62868 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL60555 | — | EC50 | = | 1000.0 | nM | 6.00 |