Assay Detail
Binding
CHEMBL763301
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Prostaglandin G/H synthase 1
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Selective cyclooxygenase-2 inhibitors: heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 4.70 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.00 |
| CHEMBL296447 | — | — | 1 | 5.96 |
| CHEMBL42561 | — | — | 1 | 4.59 |
| CHEMBL108978 | — | — | 1 | 4.50 |
| CHEMBL106151 | — | — | 1 | 4.31 |
| CHEMBL321156 | — | — | 1 | 4.26 |
| CHEMBL46712 | — | — | 1 | 4.11 |
| CHEMBL110446 | — | — | 1 | 4.09 |
| CHEMBL108961 | — | — | 1 | 4.08 |
| CHEMBL108936 | — | — | 1 | 4.05 |
| CHEMBL325755 | — | — | 1 | - |
| CHEMBL105766 | — | — | 1 | - |
| CHEMBL326005 | — | — | 1 | - |
| CHEMBL321881 | — | — | 1 | - |
| CHEMBL110331 | — | — | 1 | - |
| CHEMBL320318 | — | — | 1 | - |
| CHEMBL110448 | — | — | 1 | - |
| CHEMBL325790 | — | — | 1 | - |
| CHEMBL323277 | — | — | 1 | - |
| CHEMBL321407 | — | — | 1 | - |
| CHEMBL321898 | — | — | 1 | - |
| CHEMBL110145 | — | — | 1 | - |
| CHEMBL320330 | — | — | 1 | - |
| CHEMBL419561 | — | — | 1 | - |
| CHEMBL320986 | — | — | 1 | - |
| CHEMBL107600 | — | — | 1 | - |
| CHEMBL323954 | — | — | 1 | - |
| CHEMBL110462 | — | — | 1 | - |
| CHEMBL110396 | — | — | 1 | - |
| CHEMBL320790 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL296447 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL42561 | — | IC50 | = | 25900.0 | nM | 4.59 |
| CHEMBL108978 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL106151 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL321156 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL46712 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL110446 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL108961 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL108936 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL106023 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL322720 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL110876 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL421417 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL320118 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL110660 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL320926 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL110574 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL106192 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL42225 | — | IC50 | = | 755000.0 | nM | - |
| CHEMBL109143 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL321016 | — | IC50 | = | 338000.0 | nM | - |
| CHEMBL108452 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL327078 | — | IC50 | = | 302000.0 | nM | - |
| CHEMBL322305 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL44466 | — | IC50 | = | 789000.0 | nM | - |
| CHEMBL321216 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL420479 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL109017 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL322136 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL321898 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL320790 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL110396 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL110462 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL323954 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL107600 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL320986 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL419561 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL320330 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL110145 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL321407 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL325755 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL105766 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL326005 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL321881 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL110331 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL320318 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL110448 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL325790 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL323277 | — | IC50 | > | 1000000.0 | nM | - |