Assay Detail
Binding
CHEMBL763470
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of Penicillin-binding protein 2 from Escherichia coli.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Peptidoglycan D,D-transpeptidase MrdA (CHEMBL1840) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli K-12 |
Publication
Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.66 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333330 | — | — | 1 | 4.85 |
| CHEMBL6461 | Ro-481220 | — | 1 | 4.47 |
| CHEMBL332565 | — | — | 1 | - |
| CHEMBL121924 | — | — | 1 | - |
| CHEMBL123481 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333330 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL6461 | Ro-481220 | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL332565 | — | IC50 | = | 143000.0 | nM | - |
| CHEMBL121924 | — | IC50 | = | 145000.0 | nM | - |
| CHEMBL123481 | — | IC50 | = | 297000.0 | nM | - |