Assay Detail
Binding
CHEMBL763482
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human recombinant Prostaglandin G/H synthase 1
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
3,4-diarylthiophenes are selective COX-2 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.63 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42485 | DUP-697 | — | 1 | 6.09 |
| CHEMBL98903 | — | — | 1 | 6.05 |
| CHEMBL316823 | — | — | 1 | 5.75 |
| CHEMBL328837 | — | — | 1 | 5.28 |
| CHEMBL97874 | — | — | 1 | 5.00 |
| CHEMBL319306 | — | — | 1 | - |
| CHEMBL100422 | — | — | 1 | - |
| CHEMBL319072 | — | — | 1 | - |
| CHEMBL97935 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42485 | DUP-697 | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL98903 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL316823 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL328837 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL97874 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL319306 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL100422 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL319072 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL97935 | — | IC50 | > | 100000.0 | nM | - |