Assay Detail
Binding
CHEMBL763485
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Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Diarylspiro[2.4]heptenes as orally active, highly selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.92 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432945 | — | — | 1 | 8.30 |
| CHEMBL88717 | — | — | 1 | 6.85 |
| CHEMBL312822 | — | — | 1 | 6.51 |
| CHEMBL313387 | — | — | 1 | 6.42 |
| CHEMBL313313 | — | — | 1 | 6.40 |
| CHEMBL88532 | — | — | 1 | 6.32 |
| CHEMBL330314 | — | — | 1 | 6.30 |
| CHEMBL89089 | — | — | 1 | 6.24 |
| CHEMBL314297 | — | — | 1 | 6.13 |
| CHEMBL314225 | — | — | 1 | 6.04 |
| CHEMBL89429 | — | — | 1 | 5.88 |
| CHEMBL88549 | — | — | 1 | 5.85 |
| CHEMBL88649 | — | — | 1 | 5.75 |
| CHEMBL315585 | — | — | 1 | 5.55 |
| CHEMBL327384 | — | — | 1 | 5.51 |
| CHEMBL89625 | — | — | 1 | 5.47 |
| CHEMBL92102 | — | — | 1 | 5.39 |
| CHEMBL92154 | — | — | 1 | 5.27 |
| CHEMBL17184 | — | — | 1 | 5.27 |
| CHEMBL88286 | — | — | 1 | 5.22 |
| CHEMBL88493 | — | — | 1 | 4.79 |
| CHEMBL89578 | — | — | 1 | 4.74 |
| CHEMBL92107 | — | — | 1 | - |
| CHEMBL88550 | — | — | 1 | - |
| CHEMBL328146 | — | — | 1 | - |
| CHEMBL90447 | — | — | 1 | - |
| CHEMBL89263 | — | — | 1 | - |
| CHEMBL329999 | — | — | 1 | - |
| CHEMBL327900 | — | — | 1 | - |
| CHEMBL274893 | SC-57666 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432945 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL88717 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL312822 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL313387 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL313313 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL88532 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL330314 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL89089 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL314297 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL314225 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL89429 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL88549 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL88649 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL315585 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL327384 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL89625 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL92102 | — | IC50 | = | 4040.0 | nM | 5.39 |
| CHEMBL92154 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL17184 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL88286 | — | IC50 | = | 6010.0 | nM | 5.22 |
| CHEMBL88493 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL89578 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL558340 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL88899 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL86363 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL91258 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL315520 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL274893 | SC-57666 | IC50 | > | 1000000.0 | nM | - |
| CHEMBL327900 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL329999 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL89263 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL90447 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL328146 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL88550 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL92107 | — | IC50 | > | 100000.0 | nM | - |