Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL763577

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibitory activity against Phosphatidylinositol 3-Kinase
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Studies on the mechanism of phosphatidylinositol 3-kinase inhibition by wortmannin and related analogs.
Norman BH, Shih C, Toth JE, Ray JE, Dodge JA, Johnson DW, Rutherford PG, Schultz RM, Worzalla JF, Vlahos CJ.
J Med Chem (1996) 39 : 1106 -1111
PubMed 8676346 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 7.23 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL273832 1 9.30
CHEMBL428496 WORTMANNIN 1 8.38
CHEMBL13513 1 7.77
CHEMBL13353 1 7.28
CHEMBL268976 1 7.27
CHEMBL275722 1 7.23
CHEMBL13359 1 7.11
CHEMBL13430 1 6.82
CHEMBL276894 1 6.57
CHEMBL13142 1 6.51
CHEMBL13512 1 5.34
CHEMBL12997 1 -
CHEMBL13330 1 -
CHEMBL416892 1 -
CHEMBL273961 1 -
CHEMBL275536 1 -
CHEMBL276384 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL273832 IC50 = 0.5 nM 9.30
CHEMBL428496 WORTMANNIN IC50 = 4.2 nM 8.38
CHEMBL13513 IC50 = 17.0 nM 7.77
CHEMBL13353 IC50 = 52.0 nM 7.28
CHEMBL268976 IC50 = 54.0 nM 7.27
CHEMBL275722 IC50 = 59.0 nM 7.23
CHEMBL13359 IC50 = 77.0 nM 7.11
CHEMBL13430 IC50 = 153.0 nM 6.82
CHEMBL276894 IC50 = 271.0 nM 6.57
CHEMBL13142 IC50 = 309.0 nM 6.51
CHEMBL13512 IC50 = 4600.0 nM 5.34
CHEMBL12997 IC50 > 500.0 nM -
CHEMBL13330 IC50 > 500.0 nM -
CHEMBL416892 IC50 > 500.0 nM -
CHEMBL273961 IC50 > 500.0 nM -
CHEMBL275536 IC50 > 500.0 nM -
CHEMBL276384 IC50 > 500.0 nM -