Assay Detail
Binding
CHEMBL763599
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Protein kinase C alpha
12
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.13 | 4.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL326711 | — | — | 4 | 4.23 |
| CHEMBL117114 | — | — | 2 | 4.09 |
| CHEMBL370100 | REBECCAMYCIN | — | 1 | - |
| CHEMBL3350558 | — | — | 1 | - |
| CHEMBL3350557 | — | — | 1 | - |
| CHEMBL332728 | — | — | 2 | - |
| CHEMBL3350560 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL326711 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL326711 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL117114 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL326711 | — | IC50 | = | 99000.0 | nM | 4.00 |
| CHEMBL370100 | REBECCAMYCIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL3350558 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL117114 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3350557 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL326711 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL332728 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3350560 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL332728 | — | IC50 | > | 100000.0 | nM | - |