Assay Detail
Binding
CHEMBL763744
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Tested in vitro for inhibitory activity against Protease
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human betaherpesvirus 5 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Capsid scaffolding protein (CHEMBL3771) ↗| Type | SINGLE PROTEIN |
| Organism | Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) |
Publication
Pyrrolidine-5,5-trans-lactams as novel mechanism-based inhibitors of human cytomegalovirus protease. Part 3: potency and plasma stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.08 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299435 | — | — | 1 | 6.47 |
| CHEMBL295394 | — | — | 1 | 5.85 |
| CHEMBL45799 | — | — | 1 | 5.68 |
| CHEMBL49877 | — | — | 1 | 5.29 |
| CHEMBL431337 | — | — | 1 | 5.18 |
| CHEMBL446658 | — | — | 1 | 5.05 |
| CHEMBL301787 | — | — | 1 | 4.80 |
| CHEMBL48421 | — | — | 1 | 4.66 |
| CHEMBL45899 | — | — | 1 | 4.40 |
| CHEMBL48639 | — | — | 1 | 4.39 |
| CHEMBL297341 | — | — | 1 | 4.14 |
| CHEMBL47226 | — | — | 1 | - |
| CHEMBL48562 | — | — | 1 | - |
| CHEMBL46944 | — | — | 1 | - |
| CHEMBL49788 | — | — | 1 | - |
| CHEMBL431158 | — | — | 1 | - |
| CHEMBL296301 | — | — | 1 | - |
| CHEMBL49731 | — | — | 1 | - |
| CHEMBL298170 | — | — | 1 | - |
| CHEMBL47429 | — | — | 1 | - |
| CHEMBL300091 | — | — | 1 | - |
| CHEMBL298789 | — | — | 1 | - |
| CHEMBL50373 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299435 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL295394 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL45799 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL49877 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL431337 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL446658 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL301787 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL48421 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL45899 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL48639 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL297341 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL47226 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL48562 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL46944 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL49788 | — | IC50 | ~ | 500000.0 | nM | - |
| CHEMBL431158 | — | IC50 | ~ | 500000.0 | nM | - |
| CHEMBL296301 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL49731 | — | IC50 | ~ | 500000.0 | nM | - |
| CHEMBL298170 | — | IC50 | = | 148000.0 | nM | - |
| CHEMBL47429 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL300091 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL298789 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL50373 | — | IC50 | ~ | 500000.0 | nM | - |