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Target Snapshot

CHEMBL3771 Target Snapshot

Capsid scaffolding protein · SINGLE PROTEIN · Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)

268Compounds
15Assays
0Approved Drugs
268.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P16753. Use UniProt P16753 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P16753 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Capsid scaffolding protein as ChEMBL target CHEMBL3771, mapped to UniProt P16753. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Capsid scaffolding protein
SINGLE PROTEIN · Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
As of 2026-09-14
ChEMBL target ID
CHEMBL3771
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P16753
Capsid scaffolding protein
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Capsid scaffolding protein is the right protein anchor across sources, using UniProt P16753 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCapsid scaffolding protein
UniProt AccessionP16753
Component TypeProtein
Sequence Length708 aa

Capsid scaffolding protein

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Capsid scaffolding protein, mapped to UniProt P16753. Sequence length is 708 aa.

Mapped IDP16753
Review nameCapsid scaffolding protein
OrganismHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Clinical Profile

Clinical Phase Distribution

1
Phase III
Assay Mix

Activity Type Distribution

IC50238.0
KI26.0
EC504.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL343154 9.51 Ki 0.31 Preclinical
CHEMBL5851751 9.3 EC50 0.5 Preclinical
CHEMBL336034 8.7 Ki 2.0 Preclinical
CHEMBL344039 8.7 Ki 2.0 Preclinical
CHEMBL56849 8.57 IC50 2.7 Preclinical
CHEMBL293262 8.55 IC50 2.8 Preclinical
CHEMBL56210 8.51 IC50 3.1 Preclinical
CHEMBL299043 8.49 IC50 3.2 Preclinical
CHEMBL442168 8.49 IC50 3.2 Preclinical
CHEMBL433457 8.47 IC50 3.4 Preclinical
Distribution

pChEMBL Value Distribution

19
5.0
31
5.5
34
6.0
23
6.5
23
7.0
22
7.5
23
8.0
5
8.5
1
9.0
1
9.5
pChEMBL
Assay Landscape

Assay Landscape

15
Total Assays
154
Tested Compounds
2
Assay Types
Binding — 13 assays, 154 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 12 150 6.1
assay format 1 4 6.6
Functional — 2 assays, 43 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 43 7.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine