Compound Detail
CHEMBL5851751
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Basic Information
| ChEMBL ID | CHEMBL5851751 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SLYMJSGMJWGMJB-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
543.7
MW (Da)
6.30
ALogP
9
HBA
1
HBD
114.9
PSA (Ų)
0.13
QED
2
Ro5 Violations
22
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 9.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Capsid scaffolding protein CHEMBL3771 | EC50 | 9.3 | 9.3 | 0.5 | 1 |
| HIV-1 protease CHEMBL4296312 | EC50 | 7.52 | 7.52 | 30.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | EC50 | 6.96 | 6.96 | 110.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Capsid scaffolding protein | EC50 | = | 0.5 | nM | 9.3 | HCMV antiviral assay: Antiviral assays for HCMV DNA were carried out by DNA hybr... | - |
| HIV-1 protease | EC50 | = | 30.0 | nM | 7.52 | HSV-1 Antiviral Assay: Subconfluent MRC-5 cells in 24-well culture dishes were i... | - |
| Fibroblast growth factor receptor 1 | EC50 | = | 110.0 | nM | 6.96 | CPE reduction assay: The activity of cidofovir (CDV), cyclic cidofovir (cCDV), a... | - |
Data from ChEMBL 36 via Core Engine