Assay Detail
Binding
CHEMBL763763
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Inhibitory activity against phenylethanolamine N-methyl-transferase
69
Total Activities
69
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Phenylethanolamine N-methyltransferase (CHEMBL2331) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Importance of the aromatic ring in adrenergic amines. 5. Nonaromatic analogues of phenylethanolamine as inhibitors of phenylethanolamine N-methyltransferase: role of hydrophobic and steric interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 69 | 4.78 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18718 | — | — | 1 | 5.22 |
| CHEMBL278978 | — | — | 1 | 5.22 |
| CHEMBL18486 | CYCLONONANECARBALDEHYDE | — | 1 | 5.22 |
| CHEMBL18686 | — | — | 1 | 5.16 |
| CHEMBL280477 | — | — | 1 | 5.10 |
| CHEMBL277996 | CYCLOHEPTANE CARBALDEHYDE | — | 1 | 5.10 |
| CHEMBL275870 | — | — | 1 | 5.10 |
| CHEMBL18921 | — | — | 1 | 5.10 |
| CHEMBL18707 | — | — | 1 | 5.10 |
| CHEMBL18302 | — | — | 1 | 5.05 |
| CHEMBL279363 | CYCLOUNDECANE CARBALDEHYDE | — | 1 | 5.05 |
| CHEMBL19170 | — | — | 1 | 5.05 |
| CHEMBL18970 | — | — | 1 | 4.85 |
| CHEMBL276087 | CYCLONONANONE | — | 1 | 4.77 |
| CHEMBL278410 | — | — | 1 | 4.77 |
| CHEMBL278693 | — | — | 1 | 4.77 |
| CHEMBL18481 | — | — | 1 | 4.42 |
| CHEMBL18594 | — | — | 1 | 4.28 |
| CHEMBL278921 | — | — | 1 | 4.24 |
| CHEMBL18878 | — | — | 1 | 4.14 |
| CHEMBL19000 | — | — | 1 | 4.14 |
| CHEMBL18737 | CYCLOOCTANONE | — | 1 | 4.14 |
| CHEMBL275390 | — | — | 1 | 4.05 |
| CHEMBL18945 | — | — | 1 | - |
| CHEMBL280259 | — | — | 1 | - |
| CHEMBL275140 | — | — | 1 | - |
| CHEMBL18634 | — | — | 1 | - |
| CHEMBL275388 | — | — | 1 | - |
| CHEMBL19249 | — | — | 1 | - |
| CHEMBL278058 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18718 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL18486 | CYCLONONANECARBALDEHYDE | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL278978 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL18686 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL280477 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL277996 | CYCLOHEPTANE CARBALDEHYDE | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL275870 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL18921 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL18707 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL279363 | CYCLOUNDECANE CARBALDEHYDE | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL19170 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL18302 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL18970 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL278693 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL278410 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL276087 | CYCLONONANONE | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL18481 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL18594 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL278921 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL19000 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL18737 | CYCLOOCTANONE | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL18878 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL275390 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL18654 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL18585 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL280235 | — | IC50 | = | 510000.0 | nM | - |
| CHEMBL18294 | — | IC50 | = | 109000.0 | nM | - |
| CHEMBL18104 | HEPTANAL | IC50 | = | 109000.0 | nM | - |
| CHEMBL18666 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL274711 | CYCLOPENTANECARBALDEHYDE | IC50 | = | 446000.0 | nM | - |
| CHEMBL18278 | — | IC50 | = | 403000.0 | nM | - |
| CHEMBL18384 | — | IC50 | = | 216000.0 | nM | - |
| CHEMBL18549 | — | IC50 | = | 664000.0 | nM | - |
| CHEMBL18828 | — | IC50 | = | 403000.0 | nM | - |
| CHEMBL18407 | OCTANAL | IC50 | = | 216000.0 | nM | - |
| CHEMBL18893 | — | IC50 | = | 669000.0 | nM | - |
| CHEMBL429382 | — | IC50 | = | 195000.0 | nM | - |
| CHEMBL18542 | — | IC50 | = | 109000.0 | nM | - |
| CHEMBL280453 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL18843 | — | IC50 | = | 345000.0 | nM | - |
| CHEMBL280331 | HEXANAL | IC50 | = | 314000.0 | nM | - |
| CHEMBL18444 | — | IC50 | = | 664000.0 | nM | - |
| CHEMBL18982 | — | IC50 | = | 446000.0 | nM | - |
| CHEMBL278058 | — | IC50 | = | 195000.0 | nM | - |
| CHEMBL19249 | — | IC50 | = | 510000.0 | nM | - |
| CHEMBL275388 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL18634 | — | IC50 | = | 664000.0 | nM | - |
| CHEMBL275140 | — | IC50 | = | 760000.0 | nM | - |
| CHEMBL280259 | — | IC50 | = | 403000.0 | nM | - |
| CHEMBL18945 | — | IC50 | = | 545000.0 | nM | - |