Assay Detail
Binding
CHEMBL763768
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In vitro inhibitory activity measured against bovine adrenal phenylethanolamine N-methyltransferase(PNMT)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Phenylethanolamine N-methyltransferase (CHEMBL2331) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.45 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287837 | — | — | 1 | 6.62 |
| CHEMBL342957 | — | — | 1 | 6.42 |
| CHEMBL60068 | — | — | 1 | 5.62 |
| CHEMBL60434 | — | — | 1 | 5.52 |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | — | 1 | 4.99 |
| CHEMBL59994 | — | — | 1 | 4.62 |
| CHEMBL60724 | — | — | 1 | 4.39 |
| CHEMBL11912 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287837 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL342957 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL60068 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL60434 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | Ki | = | 10300.0 | nM | 4.99 |
| CHEMBL59994 | — | Ki | = | 23900.0 | nM | 4.62 |
| CHEMBL60724 | — | Ki | = | 40500.0 | nM | 4.39 |
| CHEMBL11912 | — | Ki | > | 2000000.0 | nM | - |