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Assay Detail

CHEMBL763773

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Binding
Inhibition of phenylethanolamine N-methyl-transferase (PNMT)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Phenylethanolamine N-methyltransferase (CHEMBL2331)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Conformational and steric aspects of the inhibition of phenylethanolamine N-methyltransferase by benzylamines.
Grunewald GL, Sall DJ, Monn JA.
J Med Chem (1988) 31 : 433 -444
PubMed 3339613 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 4.71 5.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL60434 1 5.52
CHEMBL14346 1,2,3,4-TETRAHYDROISOQUINOLINE 1 4.99
CHEMBL30294 1 4.82
CHEMBL95456 1 4.48
CHEMBL139791 1 4.28
CHEMBL138793 1 4.15
CHEMBL341582 1 -
CHEMBL337792 1 -
CHEMBL60005 1 -
CHEMBL140035 1 -
CHEMBL140069 1 -
CHEMBL134309 1 -
CHEMBL342629 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL60434 Ki = 3000.0 nM 5.52
CHEMBL14346 1,2,3,4-TETRAHYDROISOQUINOLINE Ki = 10300.0 nM 4.99
CHEMBL30294 Ki = 15000.0 nM 4.82
CHEMBL95456 Ki = 33100.0 nM 4.48
CHEMBL139791 Ki = 52000.0 nM 4.28
CHEMBL138793 Ki = 70100.0 nM 4.15
CHEMBL341582 Ki > 2000000.0 nM -
CHEMBL337792 Ki > 2000000.0 nM -
CHEMBL60005 Ki > 1000000.0 nM -
CHEMBL140035 Ki = 153000.0 nM -
CHEMBL140069 Ki = 612000.0 nM -
CHEMBL134309 Ki = 174000.0 nM -
CHEMBL342629 Ki = 479000.0 nM -