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Assay Detail

CHEMBL763979

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of human platelet aggregation induced by ADP after 3 min incubation with platelet rich plasma
ChEMBL ↗
69
Total Activities
69
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Tissue Plasma
Confidence 1 — Organism
Curated By Expert

Target

Homo sapiens (CHEMBL372) ↗
Type ORGANISM
Organism Homo sapiens

Publication

Inhibitors of blood platelet cAMP phosphodiesterase. 4. Structural variation of the side-chain terminus of water-soluble 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives.
Meanwell NA, Hewawasam P, Thomas JA, Wright JJ, Russell JW, Gamberdella M, Goldenberg HJ, Seiler SM, Zavoico GB.
J Med Chem (1993) 36 : 3251 -3264
PubMed 8230115 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 69 9.74 10.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1203038 — — 1 10.92
CHEMBL1203039 — — 1 10.92
CHEMBL1203053 — — 1 10.80
CHEMBL1203033 — — 1 10.77
CHEMBL1203084 — — 1 10.70
CHEMBL1203055 — — 1 10.70
CHEMBL1203050 — — 1 10.68
CHEMBL1203032 — — 1 10.60
CHEMBL1203087 — — 1 10.57
CHEMBL1203024 — — 1 10.52
CHEMBL1203018 — — 1 10.52
CHEMBL1203036 — — 1 10.51
CHEMBL1203034 — — 1 10.49
CHEMBL1203021 — — 1 10.47
CHEMBL1203029 — — 1 10.42
CHEMBL1203031 — — 1 10.41
CHEMBL1203086 — — 1 10.41
CHEMBL1203085 — — 1 10.38
CHEMBL1203063 — — 1 10.38
CHEMBL1203044 — — 1 10.32
CHEMBL1203040 — — 1 10.29
CHEMBL1203017 — — 1 10.27
CHEMBL1203030 — — 1 10.17
CHEMBL1203082 — — 1 10.15
CHEMBL1203052 — — 1 10.14
CHEMBL1203019 — — 1 10.14
CHEMBL1203041 — — 1 10.09
CHEMBL1203051 — — 1 10.08
CHEMBL1203020 — — 1 10.03
CHEMBL109445 — — 1 10.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1203038 — IC50 = 0.012 nM 10.92
CHEMBL1203039 — IC50 = 0.012 nM 10.92
CHEMBL1203053 — IC50 = 0.016 nM 10.80
CHEMBL1203033 — IC50 = 0.017 nM 10.77
CHEMBL1203084 — IC50 = 0.02 nM 10.70
CHEMBL1203055 — IC50 = 0.02 nM 10.70
CHEMBL1203050 — IC50 = 0.021 nM 10.68
CHEMBL1203032 — IC50 = 0.025 nM 10.60
CHEMBL1203087 — IC50 = 0.027 nM 10.57
CHEMBL1203024 — IC50 = 0.03 nM 10.52
CHEMBL1203018 — IC50 = 0.03 nM 10.52
CHEMBL1203036 — IC50 = 0.031 nM 10.51
CHEMBL1203034 — IC50 = 0.032 nM 10.49
CHEMBL1203021 — IC50 = 0.034 nM 10.47
CHEMBL1203029 — IC50 = 0.038 nM 10.42
CHEMBL1203031 — IC50 = 0.039 nM 10.41
CHEMBL1203086 — IC50 = 0.039 nM 10.41
CHEMBL1203085 — IC50 = 0.042 nM 10.38
CHEMBL1203063 — IC50 = 0.042 nM 10.38
CHEMBL1203044 — IC50 = 0.048 nM 10.32
CHEMBL1203040 — IC50 = 0.051 nM 10.29
CHEMBL1203017 — IC50 = 0.054 nM 10.27
CHEMBL1203030 — IC50 = 0.067 nM 10.17
CHEMBL1203082 — IC50 = 0.071 nM 10.15
CHEMBL1203019 — IC50 = 0.072 nM 10.14
CHEMBL1203052 — IC50 = 0.072 nM 10.14
CHEMBL1203041 — IC50 = 0.082 nM 10.09
CHEMBL1203051 — IC50 = 0.083 nM 10.08
CHEMBL1203020 — IC50 = 0.094 nM 10.03
CHEMBL109445 — IC50 = 0.1 nM 10.00
CHEMBL1203069 — IC50 = 0.11 nM 9.96
CHEMBL1203092 — IC50 = 0.13 nM 9.89
CHEMBL1203028 — IC50 = 0.13 nM 9.89
CHEMBL1203071 — IC50 = 0.13 nM 9.89
CHEMBL1203068 — IC50 = 0.16 nM 9.80
CHEMBL1203058 — IC50 = 0.16 nM 9.80
CHEMBL1203054 — IC50 = 0.16 nM 9.80
CHEMBL1203061 — IC50 = 0.16 nM 9.80
CHEMBL1203074 — IC50 = 0.18 nM 9.74
CHEMBL1203081 — IC50 = 0.23 nM 9.64
CHEMBL1203091 — IC50 = 0.28 nM 9.55
CHEMBL1203062 — IC50 = 0.28 nM 9.55
CHEMBL2447996 — IC50 = 0.29 nM 9.54
CHEMBL1203060 — IC50 = 0.3 nM 9.52
CHEMBL1203083 — IC50 = 0.31 nM 9.51
CHEMBL1203056 — IC50 = 0.32 nM 9.49
CHEMBL1203089 — IC50 = 0.32 nM 9.49
CHEMBL1203057 — IC50 = 0.35 nM 9.46
CHEMBL112418 — IC50 = 0.41 nM 9.39
CHEMBL113499 — IC50 = 0.42 nM 9.38