Assay Detail
Functional
CHEMBL763985
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested in vitro for the umolar concentration required to inhibit U-46,619-induced platelet aggregation in human platelet rich plasma (PRP)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Agents combining thromboxane receptor antagonism with thromboxane synthase inhibition: [[[2-(1H-imidazol-1-yl)ethylidene]amino]oxy]alkanoic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.16 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118188 | — | — | 1 | 6.68 |
| CHEMBL122008 | — | — | 1 | 6.55 |
| CHEMBL120041 | — | — | 1 | 6.52 |
| CHEMBL118184 | — | — | 1 | 6.43 |
| CHEMBL120181 | — | — | 1 | 6.36 |
| CHEMBL122123 | — | — | 1 | 5.68 |
| CHEMBL439790 | — | — | 1 | 5.61 |
| CHEMBL280728 | RIDOGREL | 2.0 | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118188 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL122008 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL120041 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL118184 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL120181 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL122123 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL439790 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL280728 | RIDOGREL | IC50 | = | 3300.0 | nM | 5.48 |