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Assay Detail

CHEMBL764041

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against Prostaglandin G/H synthase in an in vitro rat neutrophil assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Cyclooxygenase (CHEMBL2095157)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Antiinflammatory activity of a series of substituted 2,3-dihydro-6-hydroxypyrimido[2,1-f]purine-4,8(1H,9H)-diones.
Kaminski JJ, Solomon DM, Conn DJ, Wong SC, Chiu PJ, Massa T, Siegel MI, Watnick AS.
J Med Chem (1989) 32 : 1118 -1127
PubMed 2496230 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.22 5.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL14433 1 5.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL14433 IC50 = 6000.0 nM 5.22