Assay Detail
Binding
CHEMBL764085
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Inhibitory activity against murine prostaglandin G/H synthase 1.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.61 | 5.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7162 | NS-398 | — | 1 | 5.78 |
| CHEMBL88104 | — | — | 1 | 5.04 |
| CHEMBL315587 | — | — | 1 | 4.97 |
| CHEMBL83188 | — | — | 1 | 4.89 |
| CHEMBL87417 | — | — | 1 | 4.89 |
| CHEMBL315421 | — | — | 1 | 4.68 |
| CHEMBL7976 | CHALCONE | — | 1 | 4.66 |
| CHEMBL315813 | — | — | 1 | 4.63 |
| CHEMBL84837 | — | — | 1 | 4.63 |
| CHEMBL284742 | — | — | 1 | 4.49 |
| CHEMBL86023 | — | — | 1 | 4.40 |
| CHEMBL315053 | — | — | 1 | 4.33 |
| CHEMBL86153 | — | — | 1 | 4.24 |
| CHEMBL314588 | — | — | 1 | 4.22 |
| CHEMBL87561 | — | — | 1 | 4.22 |
| CHEMBL85649 | — | — | 1 | 4.18 |
| CHEMBL315017 | — | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7162 | NS-398 | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL88104 | — | IC50 | = | 9010.0 | nM | 5.04 |
| CHEMBL315587 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL83188 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL87417 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL315421 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL7976 | CHALCONE | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL315813 | — | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL84837 | — | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL284742 | — | IC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL86023 | — | IC50 | = | 40100.0 | nM | 4.40 |
| CHEMBL315053 | — | IC50 | = | 46200.0 | nM | 4.33 |
| CHEMBL86153 | — | IC50 | = | 57400.0 | nM | 4.24 |
| CHEMBL314588 | — | IC50 | = | 59900.0 | nM | 4.22 |
| CHEMBL87561 | — | IC50 | = | 60700.0 | nM | 4.22 |
| CHEMBL85649 | — | IC50 | = | 65300.0 | nM | 4.18 |
| CHEMBL315017 | — | IC50 | = | 80700.0 | nM | 4.09 |