Assay Detail
Functional
CHEMBL764094
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 1-monooleoyl glycerol (MOG) induced beta-hematin formation
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Histidine-rich protein PFHRP-II (CHEMBL1923) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
Synthesis and antimalarial evaluation of new 1,4-bis(3-aminopropyl)piperazine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.18 | 4.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124723 | — | — | 1 | 4.36 |
| CHEMBL331745 | — | — | 1 | 4.21 |
| CHEMBL419432 | — | — | 1 | 4.20 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.12 |
| CHEMBL125953 | — | — | 1 | 4.02 |
| CHEMBL122117 | — | — | 1 | - |
| CHEMBL419060 | — | — | 1 | - |
| CHEMBL125382 | — | — | 1 | - |
| CHEMBL122346 | — | — | 1 | - |
| CHEMBL124552 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124723 | — | IC50 | = | 43400.0 | nM | 4.36 |
| CHEMBL331745 | — | IC50 | = | 62300.0 | nM | 4.21 |
| CHEMBL419432 | — | IC50 | = | 63600.0 | nM | 4.20 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 76500.0 | nM | 4.12 |
| CHEMBL125953 | — | IC50 | = | 94700.0 | nM | 4.02 |
| CHEMBL122117 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL419060 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL125382 | — | IC50 | = | 170000.0 | nM | - |
| CHEMBL122346 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL124552 | — | IC50 | > | 200000.0 | nM | - |