Assay Detail
Binding
CHEMBL764113
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In vitro inhibitory activity against bovine adrenal phenylethanolamine N-methyl-transferase (PNMT)
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Phenylethanolamine N-methyltransferase (CHEMBL2331) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Synthesis, biochemical evaluation, and classical and three-dimensional quantitative structure-activity relationship studies of 7-substituted-1,2,3,4-tetrahydroisoquinolines and their relative affinities toward phenylethanolamine N-methyltransferase and the alpha2-adrenoceptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 5.27 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26828 | — | — | 1 | 6.43 |
| CHEMBL281289 | — | — | 1 | 6.39 |
| CHEMBL26717 | — | — | 1 | 6.26 |
| CHEMBL27664 | — | — | 1 | 5.89 |
| CHEMBL27162 | — | — | 1 | 5.85 |
| CHEMBL286497 | — | — | 1 | 5.58 |
| CHEMBL27730 | — | — | 1 | 5.58 |
| CHEMBL441679 | — | — | 1 | 5.54 |
| CHEMBL26879 | — | — | 1 | 5.31 |
| CHEMBL28390 | — | — | 1 | 5.24 |
| CHEMBL26825 | — | — | 1 | 5.17 |
| CHEMBL280592 | — | — | 1 | 5.01 |
| CHEMBL286495 | — | — | 1 | 4.96 |
| CHEMBL28431 | — | — | 1 | 4.85 |
| CHEMBL26640 | — | — | 1 | 4.68 |
| CHEMBL28340 | — | — | 1 | 4.57 |
| CHEMBL27954 | — | — | 1 | 4.35 |
| CHEMBL27776 | — | — | 1 | 4.32 |
| CHEMBL28228 | — | — | 1 | 4.19 |
| CHEMBL143953 | — | — | 1 | - |
| CHEMBL28115 | — | — | 1 | - |
| CHEMBL27639 | — | — | 1 | - |
| CHEMBL341882 | — | — | 1 | - |
| CHEMBL26667 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26828 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL281289 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL26717 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL27664 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL27162 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL286497 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL27730 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL441679 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL26879 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL28390 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL26825 | — | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL280592 | — | Ki | = | 9800.0 | nM | 5.01 |
| CHEMBL286495 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL28431 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL26640 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL28340 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL27954 | — | Ki | = | 45000.0 | nM | 4.35 |
| CHEMBL27776 | — | Ki | = | 48000.0 | nM | 4.32 |
| CHEMBL28228 | — | Ki | = | 64000.0 | nM | 4.19 |
| CHEMBL143953 | — | Ki | = | 1900000.0 | nM | - |
| CHEMBL28115 | — | Ki | = | 330000.0 | nM | - |
| CHEMBL27639 | — | Ki | ~ | 4500000.0 | nM | - |
| CHEMBL341882 | — | Ki | = | 470000.0 | nM | - |
| CHEMBL26667 | — | Ki | = | 190000.0 | nM | - |