Assay Detail
Binding
CHEMBL764115
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of PNMT (Phenylethanolamine N-Methyltransferase).
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Phenylethanolamine N-methyltransferase (CHEMBL2331) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Enantiospecific synthesis of 3-fluoromethyl-, 3-hydroxymethyl-, and 3-chloromethyl-1,2,3,4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 5.93 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287837 | — | — | 1 | 6.66 |
| CHEMBL293700 | — | — | 1 | 6.62 |
| CHEMBL304872 | — | — | 1 | 6.60 |
| CHEMBL135959 | — | — | 1 | 6.55 |
| CHEMBL41647 | — | — | 1 | 6.47 |
| CHEMBL337144 | — | — | 1 | 6.42 |
| CHEMBL337156 | — | — | 1 | 6.33 |
| CHEMBL136475 | — | — | 1 | 6.33 |
| CHEMBL342625 | — | — | 1 | 6.32 |
| CHEMBL136304 | — | — | 1 | 6.29 |
| CHEMBL138677 | — | — | 1 | 6.28 |
| CHEMBL97282 | — | — | 1 | 6.27 |
| CHEMBL26717 | — | — | 1 | 6.25 |
| CHEMBL61490 | — | — | 1 | 6.25 |
| CHEMBL39928 | — | — | 1 | 6.19 |
| CHEMBL95873 | — | — | 1 | 6.18 |
| CHEMBL136361 | — | — | 1 | 6.18 |
| CHEMBL137286 | — | — | 1 | 6.16 |
| CHEMBL290890 | — | — | 1 | 6.13 |
| CHEMBL139495 | — | — | 1 | 6.06 |
| CHEMBL62034 | — | — | 1 | 6.05 |
| CHEMBL336026 | — | — | 1 | 6.01 |
| CHEMBL293023 | — | — | 1 | 6.00 |
| CHEMBL60068 | — | — | 1 | 5.96 |
| CHEMBL40081 | — | — | 1 | 5.96 |
| CHEMBL57966 | — | — | 1 | 5.89 |
| CHEMBL121531 | — | — | 1 | 5.82 |
| CHEMBL135957 | — | — | 1 | 5.72 |
| CHEMBL60434 | — | — | 1 | 5.68 |
| CHEMBL343389 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287837 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL293700 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL304872 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL135959 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL41647 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL337144 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL337156 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL136475 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL342625 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL136304 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL138677 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL97282 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL26717 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL61490 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL39928 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL95873 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL136361 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL137286 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL290890 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL139495 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL62034 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL336026 | — | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL293023 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL60068 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL40081 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL57966 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL121531 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL135957 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL60434 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL343389 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL135908 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL137607 | — | Ki | = | 9900.0 | nM | 5.00 |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL342411 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL61489 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL59994 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL294079 | — | Ki | = | 38000.0 | nM | 4.42 |