Assay Detail
Binding
CHEMBL764161
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [32P]ATP incorporated (phosphorylation) into glutamate-tyrosine copolymer substrate by mouse platelet-derived growth factor receptor beta
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor beta (CHEMBL2749) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Structure-activity relationships for 5-substituted 1-phenylbenzimidazoles as selective inhibitors of the platelet-derived growth factor receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.92 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL312269 | — | — | 1 | 6.82 |
| CHEMBL78698 | — | — | 1 | 6.80 |
| CHEMBL80915 | — | — | 1 | 6.77 |
| CHEMBL77407 | — | — | 1 | 6.62 |
| CHEMBL78444 | — | — | 1 | 6.60 |
| CHEMBL308245 | — | — | 1 | 6.57 |
| CHEMBL309035 | — | — | 1 | 6.55 |
| CHEMBL310137 | — | — | 1 | 6.51 |
| CHEMBL310726 | — | — | 1 | 6.50 |
| CHEMBL306184 | — | — | 1 | 6.43 |
| CHEMBL76202 | — | — | 1 | 6.37 |
| CHEMBL80873 | — | — | 1 | 6.36 |
| CHEMBL77261 | — | — | 1 | 6.35 |
| CHEMBL311318 | — | — | 1 | 6.21 |
| CHEMBL311777 | — | — | 1 | 6.19 |
| CHEMBL77242 | — | — | 1 | 6.14 |
| CHEMBL80810 | — | — | 1 | 6.13 |
| CHEMBL311574 | — | — | 1 | 6.06 |
| CHEMBL77712 | — | — | 1 | 6.00 |
| CHEMBL76962 | — | — | 1 | 6.00 |
| CHEMBL79177 | — | — | 1 | 5.92 |
| CHEMBL80510 | — | — | 1 | 5.89 |
| CHEMBL75969 | — | — | 1 | 5.82 |
| CHEMBL80651 | — | — | 1 | 5.66 |
| CHEMBL311449 | — | — | 1 | 5.64 |
| CHEMBL311913 | — | — | 1 | 5.60 |
| CHEMBL79328 | — | — | 1 | 5.51 |
| CHEMBL419653 | — | — | 1 | 5.48 |
| CHEMBL77032 | — | — | 1 | 5.37 |
| CHEMBL309270 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL312269 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL78698 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL80915 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL77407 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL78444 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL308245 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL309035 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL310137 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL310726 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL306184 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL76202 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL80873 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL77261 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL311318 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL311777 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL77242 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL80810 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL311574 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL77712 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL76962 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL79177 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL80510 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL75969 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL80651 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL311449 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL311913 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL79328 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL419653 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL77032 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL309270 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL77412 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL310080 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL75964 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL80171 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL77303 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL75637 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL307817 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL76839 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL80558 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL308385 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL443800 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL310243 | — | IC50 | > | 50000.0 | nM | - |