Assay Detail
Binding
CHEMBL764167
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Platelet-derived growth factor receptor beta autophosphorylation in Rat aorta vascular smooth muscle cells(RAVSMC)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor (PDGFr) (CHEMBL2111344) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationships for 5-substituted 1-phenylbenzimidazoles as selective inhibitors of the platelet-derived growth factor receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.31 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL80873 | — | — | 1 | 6.89 |
| CHEMBL76202 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL80873 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL76202 | — | IC50 | = | 1900.0 | nM | 5.72 |