Assay Detail
Binding
CHEMBL764175
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Inhibitory activity of compound against bovine purine nucleoside phosphorylase (PNP)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 10.44 | 10.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218291 | FORODESINE | 4.0 | 1 | 10.64 |
| CHEMBL473922 | — | — | 1 | 10.52 |
| CHEMBL2311112 | — | — | 1 | 10.38 |
| CHEMBL41949 | — | — | 1 | 10.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218291 | FORODESINE | Ki | = | 0.023 | nM | 10.64 |
| CHEMBL473922 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL2311112 | — | Ki | = | 0.042 | nM | 10.38 |
| CHEMBL41949 | — | Ki | = | 0.06 | nM | 10.22 |