Assay Detail
Functional
CHEMBL764349
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against cPLA2 (cytosolic Phospholipase A2) by measuring the calcium ionophore A-23,187-induced arachidonic acid release from bovine platelets
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis, biological evaluation, and structure-activity relationships of 3-acylindole-2-carboxylic acids as inhibitors of the cytosolic phospholipase A2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 5.25 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87987 | — | — | 1 | 6.30 |
| CHEMBL91419 | — | — | 1 | 5.85 |
| CHEMBL90083 | — | — | 1 | 5.85 |
| CHEMBL313460 | — | — | 1 | 5.80 |
| CHEMBL312824 | — | — | 1 | 5.80 |
| CHEMBL91323 | — | — | 1 | 5.80 |
| CHEMBL91502 | — | — | 1 | 5.80 |
| CHEMBL90297 | — | — | 1 | 5.72 |
| CHEMBL89888 | — | — | 1 | 5.52 |
| CHEMBL91612 | — | — | 1 | 5.40 |
| CHEMBL88762 | — | — | 1 | 5.39 |
| CHEMBL90527 | — | — | 1 | 5.37 |
| CHEMBL91625 | — | — | 1 | 5.28 |
| CHEMBL313643 | — | — | 1 | 5.16 |
| CHEMBL90205 | — | — | 1 | 5.16 |
| CHEMBL328567 | — | — | 1 | 5.16 |
| CHEMBL422774 | — | — | 1 | 5.16 |
| CHEMBL327256 | — | — | 1 | 5.10 |
| CHEMBL314654 | — | — | 1 | 5.10 |
| CHEMBL90537 | — | — | 1 | 5.10 |
| CHEMBL92423 | — | — | 1 | 5.10 |
| CHEMBL90033 | — | — | 1 | 5.10 |
| CHEMBL88258 | — | — | 1 | 5.10 |
| CHEMBL330088 | — | — | 1 | 5.05 |
| CHEMBL90122 | — | — | 1 | 5.05 |
| CHEMBL90412 | — | — | 1 | 5.05 |
| CHEMBL93788 | — | — | 1 | 5.00 |
| CHEMBL316279 | — | — | 1 | 5.00 |
| CHEMBL90404 | — | — | 1 | 5.00 |
| CHEMBL91312 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87987 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL91419 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL90083 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL313460 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL312824 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL91323 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL91502 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL90297 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL89888 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL91612 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL88762 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL90527 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL91625 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL422774 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL328567 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL313643 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL90205 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL88258 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL90033 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL92423 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL314654 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL327256 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL90537 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL330088 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL90122 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL90412 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL93788 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL316279 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL90404 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL91312 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL88829 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL329898 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL281211 | ARACHIDONYL TRIFLUOROMETHYLKETONE | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL330711 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL90088 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL329600 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL313642 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL90890 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL88352 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL329539 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL279640 | — | IC50 | > | 33000.0 | nM | - |