Assay Detail
Binding
CHEMBL764359
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Inhibition of bovine heart phosphodiesterase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
Synthesis and antibronchospastic activity of 8-alkoxy- and 8-(alkylamino)imidazo[1,2-a]pyrazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.33 | 4.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114797 | — | — | 1 | 4.57 |
| CHEMBL116115 | — | — | 1 | 4.09 |
| CHEMBL430685 | — | — | 1 | - |
| CHEMBL111902 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114797 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL116115 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL430685 | — | IC50 | = | 337000.0 | nM | - |
| CHEMBL111902 | — | IC50 | = | 267000.0 | nM | - |