Heart phosphodiesterase · PROTEIN FAMILY · Bos taurus
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As of 2026-09-14Protein identity stays anchored to UniProt Q01061. Use UniProt Q01061 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q01061 as the stable identity anchor, then attach disease evidence before program review.
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Review this target as Heart phosphodiesterase, mapped to UniProt Q01061. ChEMBL maps the protein component as Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B. Sequence length is 534 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Heart phosphodiesterase as ChEMBL target CHEMBL2111408, mapped to UniProt Q01061. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Heart phosphodiesterase is the right protein anchor across sources, using UniProt Q01061 as the stable mapping.
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| Preferred Name | Heart phosphodiesterase |
| Target Type | PROTEIN FAMILY |
| Organism | Bos taurus |
| UniProt | Q01061 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B |
| UniProt Accession | Q01061 |
| Component Type | Protein |
| Sequence Length | 534 aa |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Review this target as Heart phosphodiesterase, mapped to UniProt Q01061. ChEMBL maps the protein component as Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B. Sequence length is 534 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL166121 | 5.1 | IC50 | 8000.0 | Preclinical |
| CHEMBL345196 | 5.02 | IC50 | 9600.0 | Preclinical |
| CHEMBL275084 | 5.0 | IC50 | 9900.0 | Preclinical |
| CHEMBL158723 | 4.62 | IC50 | 24000.0 | Preclinical |
| CHEMBL114797 | 4.57 | IC50 | 27000.0 | Preclinical |
| CHEMBL350705 | 4.47 | IC50 | 34000.0 | Preclinical |
| CHEMBL284323 | 4.28 | IC50 | 52000.0 | Preclinical |
| CHEMBL112904 | 4.16 | IC50 | 70000.0 | Preclinical |
| CHEMBL164128 | 4.16 | IC50 | 69000.0 | Preclinical |
| CHEMBL116115 | 4.09 | IC50 | 81000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 11 | 45 | 4.5 |