Assay Detail
Binding
CHEMBL764432
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Inhibition of [3H]1-[1-(2-thienyl) piperidine ([3H]TCP) binding to phencyclidine receptor
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Phencyclidine-like effects of tetrahydroisoquinolines and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.68 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284237 | DIZOCILPINE | 2.0 | 1 | 8.28 |
| CHEMBL279676 | TENOCYCLIDINE | 2.0 | 1 | 7.70 |
| CHEMBL275528 | PHENCYCLIDINE | 2.0 | 1 | 7.04 |
| CHEMBL21326 | — | — | 1 | 6.12 |
| CHEMBL21640 | — | — | 1 | 6.00 |
| CHEMBL21465 | — | — | 1 | 5.72 |
| CHEMBL21464 | — | — | 1 | 5.64 |
| CHEMBL21805 | — | — | 1 | 5.42 |
| CHEMBL21342 | — | — | 1 | 5.41 |
| CHEMBL283105 | — | — | 1 | 5.36 |
| CHEMBL21277 | — | — | 1 | 5.31 |
| CHEMBL21920 | — | — | 1 | 5.28 |
| CHEMBL283744 | — | — | 1 | 5.27 |
| CHEMBL22005 | — | — | 1 | 5.21 |
| CHEMBL21969 | — | — | 1 | 5.02 |
| CHEMBL282475 | — | — | 1 | 4.96 |
| CHEMBL21911 | — | — | 1 | 4.92 |
| CHEMBL21273 | — | — | 1 | 4.70 |
| CHEMBL278781 | — | — | 1 | 4.62 |
| CHEMBL283130 | — | — | 1 | - |
| CHEMBL279013 | — | — | 1 | - |
| CHEMBL21672 | — | — | 1 | - |
| CHEMBL277493 | — | — | 1 | - |
| CHEMBL22053 | — | — | 1 | - |
| CHEMBL22078 | — | — | 1 | - |
| CHEMBL22009 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284237 | DIZOCILPINE | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL279676 | TENOCYCLIDINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL275528 | PHENCYCLIDINE | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL21326 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL21640 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL21465 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL21464 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL21805 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL21342 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL283105 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL21277 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL21920 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL283744 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL22005 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL21969 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL282475 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL21911 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL21273 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL278781 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL283130 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL279013 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL21672 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL277493 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL22053 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL22078 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL22009 | — | IC50 | > | 30000.0 | nM | - |