Assay Detail
Functional
CHEMBL764452
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Effect of serum protein binding on inhibition of transformed cell line(PB HCT116) proliferation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 2. Probing the indeno ring substituent pattern.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.87 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL357770 | — | — | 1 | 6.21 |
| CHEMBL358102 | — | — | 1 | 5.91 |
| CHEMBL346164 | — | — | 1 | 5.50 |
| CHEMBL148889 | — | — | 1 | - |
| CHEMBL147290 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL357770 | — | IC50 | = | 622.0 | nM | 6.21 |
| CHEMBL358102 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL346164 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL148889 | — | IC50 | > | 5200.0 | nM | - |
| CHEMBL147290 | — | IC50 | > | 58000.0 | nM | - |