Assay Detail
Functional
CHEMBL764493
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Concentration required to inhibit replication of HIV-1 HTLV-IIIB strain in PBL (peripheral blood lymphocytes) cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBL |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.48 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.85 |
| CHEMBL288688 | — | — | 1 | 8.82 |
| CHEMBL135589 | — | — | 1 | 8.74 |
| CHEMBL337338 | — | — | 1 | 8.66 |
| CHEMBL134403 | — | — | 1 | 8.43 |
| CHEMBL36995 | — | — | 1 | 7.96 |
| CHEMBL422622 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL288688 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL135589 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL337338 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL134403 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL36995 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL422622 | — | EC50 | = | 13.0 | nM | 7.89 |