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Assay Detail

CHEMBL764523

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anti-malarial activity as growth inhibition of chloroquine-resistant Plasmodium falciparum
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Expert

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Anti-malarial activities of acylated bruceolide derivatives.
Murakami N, Umezome T, Mahmud T, Sugimoto M, Kobayashi M, Wataya Y, Kim HS.
Bioorg Med Chem Lett (1998) 8 : 459 -462
PubMed 9871598 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 18 6.39 7.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL140809 BRUCEINE B 1 7.62
CHEMBL143600 1 7.54
CHEMBL357269 1 7.46
CHEMBL140673 1 7.41
CHEMBL142229 1 7.09
CHEMBL143844 1 7.01
CHEMBL140331 1 6.41
CHEMBL265044 1 6.24
CHEMBL143011 1 6.16
CHEMBL343585 1 6.00
CHEMBL140959 1 6.00
CHEMBL140588 BRUCEOLIDE 1 5.77
CHEMBL140316 1 5.55
CHEMBL216726 1 4.80
CHEMBL141820 2 4.80
CHEMBL265045 1 -
CHEMBL136787 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL140809 BRUCEINE B EC50 = 24.0 nM 7.62
CHEMBL143600 EC50 = 29.0 nM 7.54
CHEMBL357269 EC50 = 35.0 nM 7.46
CHEMBL140673 EC50 = 39.0 nM 7.41
CHEMBL142229 EC50 = 82.0 nM 7.09
CHEMBL143844 EC50 = 98.0 nM 7.01
CHEMBL140331 EC50 = 390.0 nM 6.41
CHEMBL265044 EC50 = 570.0 nM 6.24
CHEMBL143011 EC50 = 700.0 nM 6.16
CHEMBL343585 EC50 = 1000.0 nM 6.00
CHEMBL140959 EC50 = 1000.0 nM 6.00
CHEMBL140588 BRUCEOLIDE EC50 = 1700.0 nM 5.77
CHEMBL140316 EC50 = 2800.0 nM 5.55
CHEMBL216726 EC50 = 16000.0 nM 4.80
CHEMBL141820 EC50 = 16000.0 nM 4.80
CHEMBL136787 EC50 > 1000.0 nM -
CHEMBL265045 EC50 > 1000.0 nM -
CHEMBL141820 EC50 > 1000.0 nM -