Assay Detail
Binding
CHEMBL764637
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity was tested on Phencyclidine binding assay.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Novel potent sigma 1 ligands: N-[omega-(tetralin-1-yl)alkyl]piperidine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.88 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435397 | — | — | 1 | 8.03 |
| CHEMBL127006 | — | — | 1 | 7.47 |
| CHEMBL135530 | — | — | 1 | 5.58 |
| CHEMBL134607 | — | — | 1 | 5.49 |
| CHEMBL334440 | — | — | 1 | 5.25 |
| CHEMBL135528 | — | — | 1 | 5.00 |
| CHEMBL135930 | — | — | 1 | 4.32 |
| CHEMBL135687 | — | — | 1 | - |
| CHEMBL128442 | — | — | 1 | - |
| CHEMBL336378 | — | — | 1 | - |
| CHEMBL337709 | — | — | 1 | - |
| CHEMBL134717 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435397 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL127006 | — | Ki | = | 34.2 | nM | 7.47 |
| CHEMBL135530 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL134607 | — | Ki | = | 3240.0 | nM | 5.49 |
| CHEMBL334440 | — | Ki | = | 5560.0 | nM | 5.25 |
| CHEMBL135528 | — | Ki | = | 9910.0 | nM | 5.00 |
| CHEMBL135930 | — | Ki | = | 48100.0 | nM | 4.32 |
| CHEMBL135687 | — | Ki | > | 92600.0 | nM | - |
| CHEMBL128442 | — | Ki | > | 92600.0 | nM | - |
| CHEMBL336378 | — | Ki | > | 92600.0 | nM | - |
| CHEMBL337709 | — | Ki | > | 92600.0 | nM | - |
| CHEMBL134717 | — | Ki | > | 92600.0 | nM | - |