Assay Detail
Binding
CHEMBL764638
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity was measured against phencyclidine (PCP) receptor in rat using [3H]TCP as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Novel (4-phenylpiperidinyl)- and (4-phenylpiperazinyl)alkyl-spaced esters of 1-phenylcyclopentanecarboxylic acids as potent sigma-selective compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.52 | 5.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52440 | DEXTROMETHORPHAN | 4.0 | 1 | 5.65 |
| CHEMBL60542 | (+)-PENTAZOCINE | — | 1 | 5.38 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52440 | DEXTROMETHORPHAN | Ki | = | 2246.0 | nM | 5.65 |
| CHEMBL60542 | (+)-PENTAZOCINE | Ki | = | 4190.0 | nM | 5.38 |
| CHEMBL54 | HALOPERIDOL | Ki | > | 10000.0 | nM | - |