Assay Detail
Binding
CHEMBL764684
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Inhibitory activity against plasmepsin-2
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent, low-molecular-weight non-peptide inhibitors of malarial aspartyl protease plasmepsin II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.97 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285133 | — | — | 1 | 8.70 |
| CHEMBL285177 | — | — | 1 | 8.70 |
| CHEMBL34323 | — | — | 1 | 8.52 |
| CHEMBL290115 | — | — | 1 | 8.40 |
| CHEMBL32684 | — | — | 1 | 8.39 |
| CHEMBL33989 | — | — | 1 | 8.37 |
| CHEMBL284534 | — | — | 1 | 8.32 |
| CHEMBL284955 | — | — | 1 | 8.05 |
| CHEMBL32997 | — | — | 1 | 7.00 |
| CHEMBL34051 | — | — | 1 | 6.66 |
| CHEMBL284151 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285133 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL285177 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL34323 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL290115 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL32684 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL33989 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL284534 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL284955 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL32997 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL34051 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL284151 | — | Ki | = | 300.0 | nM | 6.52 |