Assay Detail
Binding
CHEMBL764889
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Inhibitory concentration against recombinant HIV-2 protease expressed in Escherichia coli was tested by HPLC based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Potent HIV protease inhibitors containing a novel (hydroxyethyl)amide isostere.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.46 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71334 | — | — | 1 | 8.20 |
| CHEMBL66399 | — | — | 1 | 8.17 |
| CHEMBL66460 | — | — | 1 | 7.42 |
| CHEMBL304086 | — | — | 1 | 7.38 |
| CHEMBL1790508 | — | — | 1 | 6.87 |
| CHEMBL1790509 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71334 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL66399 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL66460 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL304086 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1790508 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL1790509 | — | IC50 | = | 185.0 | nM | 6.73 |