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Assay Detail

CHEMBL764897

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Binding
Binding affinity against HIV protease
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human immunodeficiency virus 2
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Human rhinovirus A protease (CHEMBL2857)
Type SINGLE PROTEIN
Organism Human rhinovirus sp.

Publication

Use of medium-sized cycloalkyl rings to enhance secondary binding: discovery of a new class of human immunodeficiency virus (HIV) protease inhibitors.
Romines KR, Watenpaugh KD, Tomich PK, Howe WJ, Morris JK, Lovasz KD, Mulichak AM, Finzel BC, Lynn JC, Horng MM.
J Med Chem (1995) 38 : 1884 -1891
PubMed 7783120 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 6.95 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL16584 1 7.82
CHEMBL54901 1 7.66
CHEMBL55619 1 7.54
CHEMBL55024 1 7.43
CHEMBL55834 1 7.24
CHEMBL55268 1 7.21
CHEMBL275899 1 7.12
CHEMBL55885 1 7.05
CHEMBL54693 1 7.02
CHEMBL293060 1 6.75
CHEMBL291483 1 6.75
CHEMBL297888 1 6.32
CHEMBL57065 1 6.25
CHEMBL292913 1 6.16
CHEMBL57231 1 5.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL16584 Ki = 15.0 nM 7.82
CHEMBL54901 Ki = 22.0 nM 7.66
CHEMBL55619 Ki = 29.0 nM 7.54
CHEMBL55024 Ki = 37.0 nM 7.43
CHEMBL55834 Ki = 57.0 nM 7.24
CHEMBL55268 Ki = 62.0 nM 7.21
CHEMBL275899 Ki = 75.0 nM 7.12
CHEMBL55885 Ki = 90.0 nM 7.05
CHEMBL54693 Ki = 96.0 nM 7.02
CHEMBL293060 Ki = 180.0 nM 6.75
CHEMBL291483 Ki = 180.0 nM 6.75
CHEMBL297888 Ki = 480.0 nM 6.32
CHEMBL57065 Ki = 560.0 nM 6.25
CHEMBL292913 Ki = 700.0 nM 6.16
CHEMBL57231 Ki = 1100.0 nM 5.96