Assay Detail
Binding
CHEMBL764905
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Inhibitory activity against porcine pancreatic elastase (PPE)
18
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Chymotrypsin-like elastase family member 2A (CHEMBL2407) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
Symmetrical anhydride-type serine protease inhibitors: structure-activity relationship studies of human chymase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.71 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134821 | — | — | 2 | 7.82 |
| CHEMBL335675 | — | — | 1 | 7.47 |
| CHEMBL108540 | — | — | 1 | 7.44 |
| CHEMBL131794 | — | — | 1 | 7.26 |
| CHEMBL131704 | — | — | 1 | 7.24 |
| CHEMBL424453 | — | — | 1 | 7.21 |
| CHEMBL436591 | — | — | 2 | 7.19 |
| CHEMBL135080 | — | — | 1 | 6.75 |
| CHEMBL134024 | — | — | 1 | 6.75 |
| CHEMBL134816 | — | — | 1 | 6.68 |
| CHEMBL134068 | — | — | 1 | 6.68 |
| CHEMBL338962 | — | — | 1 | 5.96 |
| CHEMBL134440 | — | — | 1 | 5.72 |
| CHEMBL336964 | — | — | 1 | 5.68 |
| CHEMBL134268 | — | — | 1 | 5.58 |
| CHEMBL131747 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134821 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL335675 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL108540 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL131794 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL131704 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL424453 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL436591 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL134821 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL135080 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL134024 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL134068 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL134816 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL338962 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL134440 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL336964 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL134268 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL436591 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL131747 | — | IC50 | > | 1000000.0 | nM | - |