Assay Detail
Functional
CHEMBL764945
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity at Prostanoid EP3 receptor in human was determined
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP3 subtype (CHEMBL3710) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.32 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423815 | — | — | 1 | 7.70 |
| CHEMBL166351 | — | — | 1 | 7.50 |
| CHEMBL165010 | — | — | 1 | 7.10 |
| CHEMBL350832 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423815 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL166351 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL165010 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL350832 | — | Ki | = | 110.0 | nM | 6.96 |