Compound Detail
CHEMBL350832
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL350832 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OGGSEFOELZZPRD-SOFGYWHQSA-N |
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
307.2
MW (Da)
4.68
ALogP
1
HBA
1
HBD
37.3
PSA (Ų)
0.83
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 6 meas. best 6.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP3 subtype CHEMBL3710 | Ki | 6.96 | 6.96 | 110.0 | 1 |
| Thromboxane A2 receptor CHEMBL2069 | Ki | 6.28 | 6.28 | 520.0 | 1 |
| Prostaglandin D2 receptor CHEMBL4427 | Ki | 5.6 | 5.6 | 2500.0 | 1 |
| Prostaglandin E2 receptor EP2 subtype CHEMBL1881 | Ki | 5.39 | 5.39 | 4100.0 | 1 |
| Prostacyclin receptor CHEMBL1995 | Ki | 4.51 | 4.51 | 31000.0 | 1 |
| Prostaglandin F2-alpha receptor CHEMBL1987 | Ki | 4.2 | 4.2 | 63000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP3 subtype | Ki | = | 110.0 | nM | 6.96 | Antagonistic activity at Prostanoid EP3 receptor in human was determined | 11266183 |
| Thromboxane A2 receptor | Ki | = | 520.0 | nM | 6.28 | Antagonistic activity at Thromboxane A2 receptor in human was determined | 11266183 |
| Prostaglandin D2 receptor | Ki | = | 2500.0 | nM | 5.6 | Antagonistic activity at Prostanoid DP receptor in human was determined | 11266183 |
| Prostaglandin E2 receptor EP2 subtype | Ki | = | 4100.0 | nM | 5.39 | Antagonistic activity at Prostanoid EP2 receptor in human was determined | 11266183 |
| Prostacyclin receptor | Ki | = | 31000.0 | nM | 4.51 | Antagonistic activity at Prostanoid IP receptor in human was determined | 11266183 |
| Prostaglandin F2-alpha receptor | Ki | = | 63000.0 | nM | 4.2 | Antagonistic activity at Prostanoid FP receptor in human was determined | 11266183 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11266183 | 10.1016/s0960-894x(01)00056-7 | Prostaglandin E2 receptor EP1 subtype | 1 |
| 11266183 | 10.1016/s0960-894x(01)00056-7 | Prostaglandin E2 receptor EP2 subtype | 1 |
| 11266183 | 10.1016/s0960-894x(01)00056-7 | Prostaglandin E2 receptor EP3 subtype | 1 |
| 11266183 | 10.1016/s0960-894x(01)00056-7 | Prostaglandin E2 receptor EP4 subtype | 1 |
| 11266183 | 10.1016/s0960-894x(01)00056-7 | Prostaglandin F2-alpha receptor | 1 |
| 11266183 | 10.1016/s0960-894x(01)00056-7 | Prostaglandin D2 receptor | 1 |
| 11266183 | 10.1016/s0960-894x(01)00056-7 | Prostacyclin receptor | 1 |
| 11266183 | 10.1016/s0960-894x(01)00056-7 | Thromboxane A2 receptor | 1 |
Data from ChEMBL 36 via Core Engine