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Assay Detail

CHEMBL764949

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards mouse Prostanoid EP3 receptor in CHO cells.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Prostaglandin E2 receptor EP3 subtype (CHEMBL4336)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Design and synthesis of a highly selective EP2-receptor agonist.
Tani K, Naganawa A, Ishida A, Egashira H, Sagawa K, Harada H, Ogawa M, Maruyama T, Ohuchida S, Nakai H, Kondo K, Toda M.
Bioorg Med Chem Lett (2001) 11 : 2025 -2028
PubMed 11454472 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 6.86 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL495 ALPROSTADIL 4.0 1 8.30
CHEMBL64804 1 8.30
CHEMBL293697 1 6.08
CHEMBL294585 1 5.92
CHEMBL303763 1 5.70
CHEMBL432522 1 -
CHEMBL64483 1 -
CHEMBL433249 1 -
CHEMBL61925 1 -
CHEMBL304225 1 -
CHEMBL62987 1 -
CHEMBL64358 1 -
CHEMBL64663 1 -
CHEMBL64246 1 -
CHEMBL62885 1 -
CHEMBL293242 1 -
CHEMBL64423 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL495 ALPROSTADIL Ki = 5.0 nM 8.30
CHEMBL64804 Ki = 5.0 nM 8.30
CHEMBL293697 Ki = 830.0 nM 6.08
CHEMBL294585 Ki = 1200.0 nM 5.92
CHEMBL303763 Ki = 2000.0 nM 5.70
CHEMBL432522 Ki > 10000.0 nM -
CHEMBL64483 Ki > 0.0001 nM -
CHEMBL433249 Ki > 10000.0 nM -
CHEMBL61925 Ki > 10000.0 nM -
CHEMBL304225 Ki > 0.0001 nM -
CHEMBL62987 Ki > 0.0001 nM -
CHEMBL64358 Ki > 10000.0 nM -
CHEMBL64663 Ki > 10000.0 nM -
CHEMBL64246 Ki > 10000.0 nM -
CHEMBL62885 Ki > 0.0001 nM -
CHEMBL293242 Ki > 0.0001 nM -
CHEMBL64423 Ki > 0.0001 nM -