Assay Detail
Binding
CHEMBL764950
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Evaluated for its competitive binding affinity towards mouse Prostanoid EP3 receptor in CHO cells expressing prostanoid receptor
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Prostaglandin E2 receptor EP3 subtype (CHEMBL4336) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Design and synthesis of a highly selective EP4-receptor agonist. Part 1: 3,7-dithiaPG derivatives with high selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.94 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64598 | — | — | 1 | 8.46 |
| CHEMBL304887 | — | — | 1 | 8.36 |
| CHEMBL294108 | — | — | 1 | 8.35 |
| CHEMBL495 | ALPROSTADIL | 4.0 | 1 | 8.30 |
| CHEMBL64854 | — | — | 1 | 8.21 |
| CHEMBL64254 | — | — | 1 | 7.96 |
| CHEMBL59921 | — | — | 1 | 7.14 |
| CHEMBL305568 | — | — | 1 | 7.00 |
| CHEMBL64542 | — | — | 1 | 6.89 |
| CHEMBL303787 | — | — | 1 | 6.85 |
| CHEMBL305126 | — | — | 1 | 6.66 |
| CHEMBL64217 | — | — | 1 | 6.66 |
| CHEMBL64338 | — | — | 1 | 6.37 |
| CHEMBL62888 | — | — | 1 | 6.29 |
| CHEMBL62305 | — | — | 1 | 5.96 |
| CHEMBL293856 | — | — | 1 | 5.92 |
| CHEMBL62779 | — | — | 1 | 5.52 |
| CHEMBL292717 | — | — | 1 | 5.52 |
| CHEMBL64557 | — | — | 1 | 5.35 |
| CHEMBL303532 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64598 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL304887 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL294108 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL495 | ALPROSTADIL | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL64854 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL64254 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL59921 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL305568 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL64542 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL303787 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL305126 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL64217 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL64338 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL62888 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL62305 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL293856 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL62779 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL292717 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL64557 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL303532 | — | Ki | > | 10000.0 | nM | - |