Assay Detail
Binding
CHEMBL764951
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity for mouse Prostanoid EP3 receptor expressed in CHO cells
14
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Prostaglandin E2 receptor EP3 subtype (CHEMBL4336) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Design and synthesis of a highly selective EP4-receptor agonist. Part 2: 5-thia and 9beta-haloPG derivatives with improved stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.44 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64188 | — | — | 1 | 8.92 |
| CHEMBL64187 | — | — | 1 | 8.72 |
| CHEMBL60555 | — | — | 1 | 8.70 |
| CHEMBL62868 | — | — | 1 | 8.43 |
| CHEMBL294108 | — | — | 1 | 8.35 |
| CHEMBL495 | ALPROSTADIL | 4.0 | 2 | 8.30 |
| CHEMBL292964 | — | — | 1 | 7.25 |
| CHEMBL291630 | — | — | 1 | 7.04 |
| CHEMBL439934 | — | — | 1 | 7.03 |
| CHEMBL60894 | — | — | 1 | 6.13 |
| CHEMBL64072 | — | — | 1 | 5.82 |
| CHEMBL63061 | — | — | 1 | 5.66 |
| CHEMBL293647 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64188 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL64187 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL60555 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL62868 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL294108 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL495 | ALPROSTADIL | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL495 | ALPROSTADIL | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL292964 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL291630 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL439934 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL60894 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL64072 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL63061 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL293647 | — | Ki | = | 2900.0 | nM | 5.54 |