Assay Detail
Binding
CHEMBL764959
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Effective concentration for human progesterone receptor in T47D human breast cancer cell
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Cancer cell lines |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.63 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62227 | — | — | 1 | 7.07 |
| CHEMBL64123 | — | — | 1 | 6.77 |
| CHEMBL64294 | — | — | 1 | 6.59 |
| CHEMBL65079 | — | — | 1 | 6.46 |
| CHEMBL63870 | — | — | 1 | 6.26 |
| CHEMBL294116 | — | — | 1 | - |
| CHEMBL63610 | — | — | 1 | - |
| CHEMBL65522 | — | — | 1 | - |
| CHEMBL67362 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62227 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL64123 | — | EC50 | = | 171.0 | nM | 6.77 |
| CHEMBL64294 | — | EC50 | = | 257.0 | nM | 6.59 |
| CHEMBL65079 | — | EC50 | = | 351.0 | nM | 6.46 |
| CHEMBL63870 | — | EC50 | = | 552.0 | nM | 6.26 |
| CHEMBL294116 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL63610 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL65522 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL67362 | — | EC50 | > | 1000.0 | nM | - |