Assay Detail
Binding
CHEMBL764964
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Effective concentration against PR (progesterone receptor)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel 6-aryl-1,4-dihydrobenzo[d]oxazine-2-thiones as potent, selective, and orally active nonsteroidal progesterone receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 9.46 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 9.92 |
| CHEMBL282650 | — | — | 1 | 9.42 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 9.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | EC50 | = | 0.12 | nM | 9.92 |
| CHEMBL282650 | — | EC50 | = | 0.38 | nM | 9.42 |
| CHEMBL103 | PROGESTERONE | EC50 | = | 0.92 | nM | 9.04 |