Assay Detail
Binding
CHEMBL765239
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Binding affinity for human progesterone receptor isoform A expressed in CV-1 cells
9
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Preparation, resolution, and biological evaluation of 5-aryl-1, 2-dihydro-5H-chromeno[3,4-f]quinolines: potent, orally active, nonsteroidal progesterone receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.89 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416411 | — | — | 3 | 10.00 |
| CHEMBL1160663 | — | — | 2 | 9.40 |
| CHEMBL104183 | — | — | 1 | 9.32 |
| CHEMBL94749 | — | — | 1 | 9.31 |
| CHEMBL94753 | — | — | 1 | 9.30 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 8.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416411 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL416411 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL1160663 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL104183 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL94749 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL94753 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL103 | PROGESTERONE | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL416411 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL1160663 | — | Ki | = | 60.0 | nM | 7.22 |