Assay Detail
Binding
CHEMBL765241
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration for half-maximal activation of human progesterone receptor expressed in CV-1 cells
9
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Preparation, resolution, and biological evaluation of 5-aryl-1, 2-dihydro-5H-chromeno[3,4-f]quinolines: potent, orally active, nonsteroidal progesterone receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.18 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416411 | — | — | 3 | 8.89 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 8.82 |
| CHEMBL1160663 | — | — | 2 | 8.62 |
| CHEMBL94749 | — | — | 1 | 8.57 |
| CHEMBL104183 | — | — | 1 | 8.44 |
| CHEMBL94753 | — | — | 1 | 8.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416411 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL103 | PROGESTERONE | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL1160663 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL94749 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL416411 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL104183 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL94753 | — | EC50 | = | 9.4 | nM | 8.03 |
| CHEMBL416411 | — | EC50 | = | 135.0 | nM | 6.87 |
| CHEMBL1160663 | — | EC50 | = | 147.0 | nM | 6.83 |