Assay Detail
Binding
CHEMBL765418
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Optimum inhibitory concentration required to inhibit c-GMP specific phosphodiesterase 1 (PDE1) of bovine aorta
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (CHEMBL3774) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Synthesis and evaluation of potent and selective c-GMP phosphodiesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.29 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278254 | — | — | 1 | 8.22 |
| CHEMBL18524 | — | — | 1 | 7.92 |
| CHEMBL18744 | — | — | 1 | 7.85 |
| CHEMBL18965 | — | — | 1 | 7.85 |
| CHEMBL19157 | — | — | 1 | 7.82 |
| CHEMBL274965 | — | — | 1 | 7.60 |
| CHEMBL416541 | — | — | 1 | 7.60 |
| CHEMBL19046 | — | — | 1 | 7.51 |
| CHEMBL18817 | — | — | 1 | 7.48 |
| CHEMBL18745 | — | — | 1 | 7.44 |
| CHEMBL280307 | — | — | 1 | 7.22 |
| CHEMBL18474 | — | — | 1 | 6.96 |
| CHEMBL18964 | — | — | 1 | 6.82 |
| CHEMBL277317 | — | — | 1 | 6.80 |
| CHEMBL418367 | — | — | 1 | 6.53 |
| CHEMBL275204 | — | — | 1 | 6.46 |
| CHEMBL278644 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278254 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL18524 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL18744 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL18965 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL19157 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL274965 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL416541 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL19046 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL18817 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL18745 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL280307 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL18474 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL18964 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL277317 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL418367 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL275204 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL278644 | — | IC50 | = | 1250.0 | nM | 5.90 |