Assay Detail
Binding
CHEMBL765420
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Inhibition of phosphodiesterases PDE1 from bovine aorta
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of polycyclic pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP phosphodiesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.44 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL137712 | — | — | 1 | 7.75 |
| CHEMBL140185 | — | — | 1 | 7.70 |
| CHEMBL140173 | — | — | 2 | 7.26 |
| CHEMBL137400 | — | — | 1 | 7.22 |
| CHEMBL68152 | — | — | 1 | 7.00 |
| CHEMBL71768 | — | — | 1 | 6.69 |
| CHEMBL139501 | — | — | 1 | 6.27 |
| CHEMBL343781 | — | — | 1 | 6.07 |
| CHEMBL344852 | — | — | 1 | 5.96 |
| CHEMBL343973 | — | — | 1 | 5.70 |
| CHEMBL136367 | — | — | 1 | 4.75 |
| CHEMBL343971 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL137712 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL140185 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL140173 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL137400 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL68152 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL140173 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL71768 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL139501 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL343781 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL344852 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL343973 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL136367 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL343971 | — | IC50 | = | 29000.0 | nM | 4.54 |