Assay Detail
Binding
CHEMBL765456
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Binding affinity was evaluated on serine protease plasma kallikrein.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.10 | 4.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108202 | — | — | 1 | 4.10 |
| CHEMBL108717 | — | — | 1 | - |
| CHEMBL42495 | — | — | 1 | - |
| CHEMBL441468 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108202 | — | Ki | = | 79000.0 | nM | 4.10 |
| CHEMBL108717 | — | Ki | = | 816000.0 | nM | - |
| CHEMBL42495 | — | Ki | = | 586000.0 | nM | - |
| CHEMBL441468 | — | Ki | = | 399000.0 | nM | - |