Assay Detail
Binding
CHEMBL765460
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Inhibitory activity against plasma kallikrein
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design of benzamidine-type inhibitors of factor Xa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 4.80 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL137780 | — | — | 1 | 5.12 |
| CHEMBL135815 | — | — | 1 | 5.07 |
| CHEMBL336844 | — | — | 1 | 4.92 |
| CHEMBL135998 | — | — | 1 | 4.85 |
| CHEMBL135198 | — | — | 1 | 4.75 |
| CHEMBL341933 | — | — | 1 | 4.72 |
| CHEMBL137311 | — | — | 1 | 4.54 |
| CHEMBL133027 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL137780 | — | Ki | = | 7600.0 | nM | 5.12 |
| CHEMBL135815 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL336844 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL135998 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL135198 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL341933 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL137311 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL133027 | — | Ki | = | 36000.0 | nM | 4.44 |